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Compared with mouse thymocytes, mouse ES cells contain increased levels of whole genomic H3K4me3 and have larger H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In settlement with this, global decreases in H3K4me3 levels happen during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic adjustments in H3K4me3 profiles at particular units of genes throughout ES cell differentiation.
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