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In contrast with mouse thymocytes, mouse ES cells contain increased levels of total genomic H3K4me3 and have larger H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 46 In settlement with this, world decreases in H3K4me3 ranges occur during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic modifications in H3K4me3 profiles at specific units of genes during ES cell differentiation.
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